Describe the Central Dogma of Molecular Biology The Central Dogma refers to the flow of genetic information in biological systems. According to Watson-Crick, Deoxyrobonucleic Acid (DNA) consists of two polynucleotides chains which are held together by hydrogen bonds complementary bases: Adenine (A): Thymine (T), T is however replaced with Uracil (U) in Ribonucleic Acid (RNA) and Guanine (G): Cytosine (C). The strands of polynucleotides run antiparallel, 5 to 3 end. DNA replication is the process that occurs in all the cells, whereby an entire double-stranded DNA is copied to produce a second, identical DNA double helix. It begins at specific locations in the genome, called origins. DNA replication is semi-conservative whereby each polynucleotide of the parental DNA acts as a template for base-pairing to form complementary strand. This is proven by Meselson and Stahl experiment where they grew E.coli on a heavy nitrogen isotope, 15NH4Cl for 14 generations and then transferred to a normal heavy nitrogen isotope, 14NH4Cl. The DNA in the bacteria consists of half 15N an......

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